Top Senior Machine Learning Jobs in Los Angeles, CA

Develop and operate production ML and AI systems powering patient experiences such as matching, ranking, recommendations, onboarding, and personalization. Build reusable ML infrastructure, pipelines, evaluation, observability, and model-serving capabilities. Provide technical leadership across the ML lifecycle, guide architecture, evaluate custom versus foundation-model approaches, and partner with ML and Patient Engineering teams to deliver reliable, scalable AI products.

Leads the AI Engineering team across applied AI features and foundational ML infrastructure. Responsibilities include managing Senior and Staff engineers, hiring and coaching, deploying LLM-powered capabilities, building MLOps and AI observability platforms, balancing product delivery with platform investment, and ensuring privacy, compliance, evaluation rigor, and clinical safety in production systems.

Develop and maintain production machine learning models, build scalable training and serving technologies, optimize real-time and batch ML pipelines, and monitor model performance and drift. The role involves deep neural networks, recommendation systems, automated retraining, ML research, engineering excellence, and communicating technical concepts to diverse audiences. Candidates need 6+ years of industry ML experience, strong coding skills, and experience deploying neural networks at scale.

Build and operate production machine learning systems for Safety AI, including low-latency APIs, data pipelines, model serving, evaluation, monitoring, and rollout infrastructure. Process large-scale camera and telematics data, optimize cloud and edge-to-cloud execution, track model performance and drift, and partner with applied scientists, firmware engineers, platform teams, and product managers to deliver reliable safety features.

Design and productionize causal machine learning models, including uplift modeling and treatment-effect estimation. Analyze A/B tests and quasi-experiments, develop experimentation strategies, evaluate modeling tradeoffs, and build scalable infrastructure. Collaborate with product and engineering teams, conduct code reviews, maintain engineering standards, communicate technical insights, and mentor others.

Leads and develops a team of autonomy engineers building multi-agent resource allocation, planning, coordination, and edge AI systems for spacecraft. Provides technical oversight on optimization, reinforcement learning, validation, architecture, and constrained real-time deployment. Owns team roadmaps, delivery, cross-functional dependencies, process improvement, and stakeholder communication while managing hiring, performance, career development, and team culture. The role bridges autonomy expertise with spacecraft constraints including compute, latency, power, and communication limitations.

Lead end-to-end LLM inference performance across serving systems, models, GPU hardware, and workloads. Define rigorous benchmarks, diagnose bottlenecks from scheduling through kernels and interconnects, optimize single- and multi-node deployments, and deliver production-ready runtimes and configurations. Collaborate with product and infrastructure teams, evaluate inference technologies, and implement runtime fixes. The role requires strong Python engineering, production experience with serving engines such as vLLM or SGLang, GPU profiling, and knowledge of modern inference optimization techniques.

Build and deploy production machine learning systems that optimize Samsara’s global hardware supply chain. Responsibilities include demand, inventory, lead-time, spend, and supplier-risk forecasting; anomaly detection; feature engineering and ETL; real-time inference; MLOps; data infrastructure improvements; governance; and model monitoring. The role defines the AI transformation roadmap, partners with executive and cross-functional stakeholders, mentors scientists, and drives adoption of AI-enabled operational workflows.

Design, build, and support high-throughput, low-latency LLM inference and data pipelines; collaborate with data scientists to post-train and evaluate models; implement scalable, production-ready systems with strong testing, monitoring, and performance focus; mentor engineers and iterate on architecture, reliability, and user-facing AI applications.

Develop autonomy evaluation metrics, statistical and machine-learning analyses, dashboards, and pipelines for simulation and on-road autonomous vehicle testing. Analyze perception, prediction, and planning performance; identify anomalous behavior and critical scenarios; apply VLMs and LLMs where appropriate; and support release gating and safety decisions. The role requires production Python, C++ debugging, technical leadership, cross-functional collaboration, and rigorous software engineering practices.

Lead the development and production deployment of applied machine learning and LLM solutions across product, marketing, and operations. Own ranking, recommendation, filtering, personalization, experimentation, and model evaluation systems. Partner with business and technical teams to identify valuable use cases, establish modeling best practices, and ensure reliable production deployment. Manage and mentor applied ML practitioners while maintaining technical rigor, business alignment, and measurable customer and revenue impact.

Lead the design, development, deployment, and operation of production AI and ML systems. Build high-throughput Python services and Databricks pipelines, support traditional ML and LLM applications, establish testing and deployment standards, and develop monitoring for quality, reliability, latency, throughput, and cost. Partner with product, research, and responsible AI teams on governance and release criteria. Provide architectural leadership, conduct code reviews, mentor engineers, and resolve complex technical dependencies.

Build and operationalize machine learning models for large-scale advertising optimization. Responsibilities include designing high-volume services, developing data solutions, training and evaluating models, improving calibration and guardrails, creating offline and online evaluation workflows, and monitoring production systems. The role requires collaboration with product and engineering teams, ownership of reliability and performance, participation in on-call rotations, and deploying scalable, cost-effective ML solutions.

Leads Tala’s Machine Learning Engineering team in building and operating platforms for model development, real-time inference, streaming features, batch processing, deployment, monitoring, and production reliability. Manages and develops 4–6 engineers, owns delivery and prioritization, provides architectural leadership, improves engineering practices and SLOs, and partners with Data Science, Data Engineering, Product, Credit, and Business Development teams.

Leads and develops a perception and machine learning engineering team building computer vision, sensor fusion, tracking, detection, and scene-understanding capabilities for autonomous systems. Owns roadmap planning, technical decisions, delivery, model development and deployment workflows, field readiness, hiring, performance management, and cross-functional execution with autonomy, embedded, data, hardware, product, programs, and field operations teams.

Leads modeling architecture and real-time machine learning systems for personalization, matchmaking, social recommendations, player retention, and community health. Designs graph ML, reinforcement learning, contextual bandit, and representation learning solutions while optimizing fairness, latency, scalability, and model observability. Partners across product, software, data, research, and platform teams; establishes ML standards, governance, experimentation practices, and responsible AI controls. Mentors senior engineers and data scientists and provides organization-wide technical leadership.

Design, build, and maintain optimization technology, full-stack systems, and data-intensive scheduling infrastructure. Improve optimization algorithms using linear optimization, machine learning, and generative AI. Lead complex technical initiatives, establish testing and observability, support scalable operations, troubleshoot customer issues, participate in on-call rotations, and mentor engineers while partnering closely with product and engineering teams.

The role involves developing machine learning systems for Mars atmospheric modeling and multi-modal data fusion, contributing to autonomous science in space missions.

Build and scale production AI systems for Prophetic’s real estate intelligence platform. Responsibilities include developing agentic systems, data pipelines, inference workflows, evaluation benchmarks, geospatial processing, and machine learning applications across hundreds of millions of records. The role requires shipping reliable Python services, optimizing throughput and cost, integrating research into products, and collaborating with engineering and product teams.

Leads the architecture, development, and operation of Disney’s AI and machine learning platform for finance. Responsibilities include managing a global engineering team, building production LLM applications and governed data foundations, defining AI/ML roadmaps, enforcing RBAC and engineering quality, guiding build-versus-integrate decisions, partnering with finance stakeholders, and driving enterprise adoption. The role is hands-on, involving architecture, implementation, technical reviews, code review, model evaluation, and delivery oversight.

Lead the development of machine learning systems for Cedar Pay's Personalization Engine, manage ML engineers, and ensure ML model effectiveness.

Designs, builds, and operationalizes enterprise AI, generative AI, machine learning, and agentic AI solutions. Develops integrations, orchestration services, reusable tooling, deployment pipelines, monitoring, and governance controls. Partners with architecture, platform, data, and product teams to deliver scalable, secure, compliant AI capabilities across the organization.

Lead design and productionalize ML algorithms and pipelines to detect account-sharing fraud in real time. Build scalable preprocessing, training, deployment, monitoring, and A/B testing solutions with cross-functional teams to optimize detection while minimizing user disruption.

Own the full machine learning lifecycle for search ranking and retrieval, including model training, deployment, serving, feature pipelines, evaluation frameworks, hybrid lexical-vector retrieval, large-scale embedding inference, query understanding, and permissions-aware multi-tenant search. Collaborate with infrastructure, AI, and backend teams to improve search relevance across ClickUp’s platform.

Leads the design, development, deployment, and operation of scalable machine learning solutions and high-performance microservices. Builds real-time inference systems using Triton and TensorRT, guides distributed cloud architectures, participates hands-on in coding and reviews, and mentors engineers. Drives technical strategy, operational excellence, system resilience, and business-wide innovation across generative AI, graph machine learning, and big data initiatives.