Senior Scientist, Chemoproteomics

Use Your Power for Purpose
At Pfizer we deliver breakthroughs that change patients' lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells. The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of small-molecule therapeutics, and novel payload antibody drug conjugates (ADCs).
POSITION SUMMARY
As a Senior Scientist on our Systems Biology team, your research will drive a deeper understanding of the mechanism of action of our molecules and cellular targets. You will act as a Chemoproteomics subject matter expert and participate in project teams, providing insight and technical expertise required for project progression. You will also work closely with the Medicinal Chemistry, Biochemistry, and Oncology Biology groups to innovate and develop the next generation of small-molecule and antibody-drug conjugate therapies.
KEY RESPONSIBILITIES

• Develop and deploy innovative chemical biology tools, with an emphasis on unbiased proteomic technologies, to advance portfolio projects.
• Enable small-molecule discovery and hit-to-lead through collaborations with biologists and chemists
• Actively contribute to multi-disciplinary project teams, including developing experimental plans and communication of results
• Deploy state-of-the-art chemical biology technologies for target engagement and interactome mapping through chemical probes, thermal stability (CETSA), and proximity methods.
• Enhance the external reputation of Pfizer's Chemical Biology capabilities through publications and presentations at leading conferences
• Drive innovation in all aspects of laboratory operations including sample preparation, running samples on mass spectrometers, data analysis and interpretation.

MINUMUM REQUIREMENTS

• PhD in Biological Sciences, Chemical Biology, Proteomics, or a related field.
• Experience and proficiency with protein biochemistry techniques (e.g., subcellular fractionation, western blot, in-gel fluorescence).
• Familiarity with biorthogonal chemistry (click) , site-selective protein modification, photoprobes, and activity-based protein profiling (ABPP).
• Experience with proteomic workflows and data analysis
• Excellent verbal and written communication skills.
• Examples of peer-reviewed publications from scientific work to date

• Experience working in teams of scientists to deliver objectives

PREFERRED REQUIREMENTS

• Relevant PhD degree with 3+ years of relevant postdoctoral and/or industry research experience.
• Experience with data-independent acquisition (DIA) with data processing utilizing DIANN or Spectronaut.
• Experience with automated sample preparation (Bravo AssayMAP, Kingfisher).
• Demonstrated knowledge of oncology and discovery of small-molecule therapeutics.

Work Location Assignment: Hybrid
The annual base salary for this position ranges from $90,900.00 to $151,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development