Senior Bioanalytical Scientist

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity
The Senior Bioanalytical Scientist will provide strategic bioanalytical leadership across all Praxis programs. This includes oversight of nonclinical and clinical analyses spanning small molecules, oligonucleotides and biomarkers. The scientist will support development and validation of bioanalytical assays and serve as the subject matter expert for cross-functional teams, ensuring the scientific, quality, and regulatory soundness of all data and reports. A key part of this role is managing relationships with CRO vendors, acting as the primary point of contact for project-related issues, and driving accountability to timelines. The Senior Bioanalytical Scientist will also contribute to functional area budget management, while ensuring high-quality data and timely reporting that enable critical program development milestones and advance transformative therapies for patients.

Primary Responsibilities

• Support strategy and execution of external bioanalytical method development and validation activities to support regulatory and study endpoints for small molecules and antisense oligonucleotide (ASO) nonclinical and clinical programs, using LC-MS/MS, ligand-binding, immunogenicity/ADA and other assay modalities.
• Provide bioanalytical expertise to internal and external study teams, implementing strategies across all phases of the drug development pipeline.
• Support selection and management of bioanalytical CROs, serving as the primary point of contact to oversee deliverables, performance, and compliance with statements of work and study timelines, and act as point of escalation for vendor-related issues.
• Partner with nonclinical, clinical and program development teams to oversee PK deliverables, budget strategy for outsourcing, and alignment of bioanalytical and biomarker project timelines.
• Ensure the scientific integrity, quality, and regulatory compliance of all bioanalytical projects in support of nonclinical and clinical development.
• Collaborate with discovery, nonclinical and clinical teams to inform study design and integrate pharmacodynamic, safety, and other biomarkers into the development process.
• Represent the bioanalytical/translational function on development program teams, presenting data, timelines, and progress at cross-functional meetings.
• Support authoring and review bioanalytical sections of regulatory submissions and study documents, including INDs, IBs, CTAs, and CSRs.

Qualifications and Key Success Factors

• PhD in Biological Sciences, Chemistry, or related field with 5+ years of relevant experience; MS with 8+ years of related experience; BS with 10+ years of related experience.
• Demonstrated experience in bioanalytical and biomarker (preferred) method development, validation, and sample analysis.
• Ability to provide operational strategy and scientific leadership within functional groups and cross-functional project teams.
• Strong understanding of regulatory guidance and expectations related to bioanalysis and biomarkers.
• Hands-on experience with small molecule analysis by LC-MS/MSa and large molecule by ligand binding; experience with antisense oligonucleotides (ASOs) preferred.
• Familiarity with a variety of translational assay techniques and modalities, including proteomics, metabolomics, and qPCR (preferred).
• Excellent interpersonal and communication skills, with the ability to build strong, trust-based relationships and foster collaboration across diverse teams.
• Highly organized and detail-oriented, with a proven ability to deliver high-quality results on time.
• Familiarity with Agile ways of working (WorkBoard or similar tools) preferred.

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! 

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.