Lead translational biomarker strategy and validation for clinical candidates: identify and validate pharmacology biomarkers, manage assay validation with CLIA labs/CROs, write SOPs for GSP/GCLP, coordinate with nonclinical teams for NHP and FIH studies, oversee lab operations, training, compliance and audits, and support early-phase dosing/POC biomarker decisions.
Senior Scientist, Translational Immunology
Location: South San Francisco, CA (On-site)
Parvus Therapeutics Inc.
Parvus Therapeutics Inc. is a privately held biopharmaceutical company developing Navacims™, a platform technology based on foundational research published in 2016 (Nature 530:434), to treat autoimmune diseases. Parvus’ mission is to shift the treatment paradigm toward Navacim™-directed immune regulation, avoiding non-specific immune suppression associated with current therapies. Parvus’ innovative approach has the potential to benefit millions of patients suffering from debilitating autoimmune diseases and other chronic inflammatory conditions. Parvus is advancing a pipeline of proprietary drug candidates for multiple autoimmune indications through preclinical development and into the clinic. Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization.
The Position
We are seeking a Senior Scientist to join our team and drive projects enabling the translation, validation, and execution of preclinical biomarkers to the clinic.
Primary Responsibilities:
Location: South San Francisco, CA (On-site)
Parvus Therapeutics Inc.
Parvus Therapeutics Inc. is a privately held biopharmaceutical company developing Navacims™, a platform technology based on foundational research published in 2016 (Nature 530:434), to treat autoimmune diseases. Parvus’ mission is to shift the treatment paradigm toward Navacim™-directed immune regulation, avoiding non-specific immune suppression associated with current therapies. Parvus’ innovative approach has the potential to benefit millions of patients suffering from debilitating autoimmune diseases and other chronic inflammatory conditions. Parvus is advancing a pipeline of proprietary drug candidates for multiple autoimmune indications through preclinical development and into the clinic. Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization.
The Position
We are seeking a Senior Scientist to join our team and drive projects enabling the translation, validation, and execution of preclinical biomarkers to the clinic.
Primary Responsibilities:
- Identify and validate biomarkers relevant to the pharmacology of target clinical candidates.
- Lead context-of-use validation (in-house or through CLIA-certified laboratories or clinical CROs) of clinical biomarker assays suitable for use in recommended phase 2 dosing selection and/or regulatory submission.
- Write and amend internal SOPs and reports as necessary for GSP or GCLP purposes.
- Liaise with nonclinical pharmacology and discovery immunology teams to establish proof-of-concept/proof-of-mechanism biomarker strategies suitable for use in NHPs and FIH studies.
- Participate in all aspects of lab operation, training, and compliance including external audits where applicable.
- Other duties and responsibilities as assigned.
- Bachelors degree with a minimum 10 years of experience or a Masters degree with a minimum of 6 years of experience (at least 2 years must be in biotech or industry setting) in Immunology or other relevant life sciences. Experience with regulatory T cells or Tr1 cells will be prioritized.
- Expertise in high-dimensional flow cytometry assays including but not limited to spectral flow cytometry and CyTOF.
- Experience leading phase appropriate clinical bioanalytical assay development and analyses including full validation and management of clinical bioanalytical labs/CROs.
- Experience developing lean and agile clinical biomarker budgets suitable for early phase POC and POM studies.
- Nice to have:
- Experience with nanomedicine
- Experience with IQOQ
- Familiarity with biomarker-centric platforms such as spatial profiling, multi-omics integration
- Excellent oral, written communication, and presentation skills.
- Demonstrated ability to effectively work in cross-functional teams, meet deadlines, and prioritize multiple projects is required.
- Comfortable working collaboratively in a small, fast-paced environment.
- Ability to quickly adjust to shifting project demands and priorities.
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What you need to know about the Los Angeles Tech Scene
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