Senior Scientist, Radiochemistry

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The Senior Scientist, Radiochemistry is responsible for hands-on laboratory work focused on the radiolabeling of antibodies and antibody fragments with radiometals, and for the conjugation of biomolecules with metal chelators. This role requires a strong foundation in radiochemistry, protein biochemistry, and antibody characterization. The position will support preclinical research activities in cancer theranostics and therapeutic applications, while also contributing to translational development and early CMC scale-up initiatives. The individual will serve as the Radiation Safety Officer (RSO) for the site and will ensure compliance with all radiation safety regulations and internal practices.

Key Accountabilities

• Radiochemistry & Conjugation
  • Perform and optimize radiolabeling of antibodies and antibody fragments with therapeutic and diagnostic radiometals (e.g., 177-Lu, 225-Ac, 89-Zr, 64-Cu, etc.).
  • Conduct chemical conjugation of antibodies with metal chelators (e.g., DOTA, DOTAGA, DTPA, DFO, MACROPA).
  • Develop reproducible and scalable labeling protocols for preclinical and translational applications.
  • Design and execute quality control assays (HPLC, iTLC, SEC, SDS-PAGE).
  • Develop and transfer analytical methods to support preclinical studies and CMC activities.
• Protein Biochemistry
  • Apply biochemical expertise in antibody/protein handling, purification, and characterization.
  • Assess protein integrity and stability following conjugation and radiolabeling.
  • Support analytical method development for protein-radiometal conjugates.
• Preclinical & Development Support
  • Collaborate with in-vivo biology team to support in vitro and in vivo studies.
  • Provide input into CMC scale-up activities.
  • Contribute to IND-enabling activities, including process documentation and technology transfer.
• Radiation Safety
  • Serve as the site’s Radiation Safety Officer (RSO).
  • Maintain compliance with local, state, and federal radiation safety regulations.
  • Implement radiation safety procedures, train laboratory staff, and maintain required records and licenses.

Education and Experience

• Required Qualifications
  • Bachelors plus 8+ years, Masters plus 6+ years, Ph.D. plus 5+ years in Chemistry, Biochemistry, Radiochemistry, Pharmaceutical Sciences, or related field.
  • 3+ years of laboratory experience in radiolabeling of biologics, metal chelator chemistry, and related QC techniques.
  • Strong background in protein biochemistry, including antibody purification, conjugation, and characterization.
  • Experience with analytical methods commonly applied in radiopharmaceutical and protein characterization.
  • Prior or current qualification as Radiation Safety Officer (or equivalent experience).
  • Knowledge of regulations governing radiation safety.
  • Strong documentation, organizational, and communication skills.
• Preferred Qualifications
  • Experience with preclinical radiopharmaceutical development in oncology.
  • Familiarity with CMC scale-up activities and regulatory documentation.
  • Experience with GMP or GLP environments.
• Job Competencies / Behaviors
  • Safety Mindset: Demonstrates strict adherence to radiation safety protocols and laboratory best practices.
  • Scientific Rigor: Applies a detail-oriented and methodical approach to experimental design, execution, and data analysis.
  • Collaboration: Works effectively across multidisciplinary teams, fostering open communication and knowledge sharing.
  • Accountability: Takes ownership of projects and responsibilities, delivering on commitments in a timely manner.
  • Adaptability: Adjusts to evolving project priorities, regulatory requirements, and organizational needs.
  • Problem-Solving: Approaches technical challenges with creativity and persistence, identifying practical solutions.
  • Communication: Clearly communicates experimental results, documentation, and regulatory materials to internal stakeholders and collaborators.