Principal AI Engineer

eClinical Solutions is a global leader in clinical data intelligence, delivering the elluminate® Clinical Data Cloud® — an AI-powered platform driving agentic data review, SDTM automation, and RBQM for 18 of the top 50 pharmaceutical companies worldwide.

As part of our eNOVA AI-First transformation, we are embedding AI across every pillar of clinical development and enterprise operations — compressing cycle times, improving data quality, and redefining how work gets done.

As we scale our AI capabilities, we are building a high-impact, hands-on AI engineering function focused on delivering real, production-grade automation across the enterprise.

You will make an impact

The Principal AI Engineer – Automation & AI is a hands-on technical leader responsible for designing, building, and deploying AI-powered automation solutions across eClinical Solutions.

This role is builder-first (70–80% hands-on development) and operates within a small, high-output team (2–4 engineers). You will work directly with the CTAO and business leaders to identify high-value use cases and rapidly translate them into working AI systems in production.

This is not a program management or oversight role. You are expected to build, ship, and iterate continuously, leveraging modern AI tooling and agentic frameworks to deliver measurable impact.

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare.

Your day to day:

• Actively works with product and engineering to design and build breakthrough AI-powered and agentic capabilities for our clients using LLMs, agentic workflows, and modern DL/ML techniques
• Design, prototype, develop, and test LLM-powered applications, agentic workflows, and predictive models using Python and modern AI frameworks to power critical product capabilities
• Work with both structured and unstructured clinical trial data, including patient reports, trial documentation, and free text notes
• Ideate, design, prototype, and develop solutions such as multi-agent workflows, RAG-based applications, document intelligence and summarization pipelines, and intelligent process automation
• Design, prototype, and develop solutions using modern AI frameworks and libraries such as LangChain, LangGraph, LlamaIndex, PyTorch, Hugging Face Transformers, and scikit-learn
• Champion AI-driven development practices across the team — using AI coding assistants and agentic dev tools to accelerate prototyping, code generation, testing, and review
• Build and maintain LLM, agentic, and ML pipelines, including prompt engineering, orchestration logic, and evaluation harnesses
• Apply relevant evaluation frameworks, guardrails, and statistical measures for performance, quality, and error analysis of AI systems
• Drive the entire workflow of multiple AI engineering projects
• Enhance the experience and efficiency of our elluminate software platform users
• Work with our Engineering team to integrate AI capabilities into our elluminate software platform
• Work with the MLOps/AIOps team to deploy LLM, agentic, and ML systems in production and to track performance, cost, and quality
• Consult with and assist our software development and biometrics teams to consume the results of these AI systems
• Ensure data quality throughout all stages of acquisition and processing
• Serve as Subject Matter Expert in Generative AI, agentic systems, and applied Machine Learning
• Keep up to date with the latest research and tooling in LLMs, agentic AI, and ML
• Educate other team members in modern AI techniques and best practices
• Publish and present work and contribute to company’s intellectual property
• Other duties as assigned
  

Qualifications: 

Preferred

• Experience with:
• RAG architectures and vector databases
• AI evaluation frameworks, guardrails, and monitoring
• Workflow automation tools and enterprise integrations
• Experience working in regulated environments (e.g., life sciences, healthcare, financial services)
• Familiarity with clinical data, CDISC standards, or clinical development workflows
• Experience in high-growth or PE-backed SaaS environments

Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!

eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/

eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!

We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.